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The AMR Interpretation Engine, developed by Brigham and Women’s Hospital and maintained by the WHONET team, is a standalone Clinical Decision Support tool designed to translate raw antimicrobial susceptibility data into guideline-conformant interpretations. Built to serve microbiology laboratories, infection-control officers, and software developers, the program applies both CLSI and EUCAST breakpoints to MIC or disk-diffusion measurements, instantly flagging isolates as susceptible, intermediate, or resistant. Version 26.3.26—one of eleven documented releases—ships with a comprehensive set of updated breakpoint tables located in the Interpretation Engine\Resources folder; these flat files can be consumed independently by third-party LIS, surveillance dashboards, or epidemiological scripts that prefer not to embed the full engine. Integration flexibility is central: the Interpretation Engine library exposes a public API for tight coupling within larger informatics pipelines, while a minimalist command-line wrapper enables scripted batch processing of CSV or WHONET-formatted input files without any coding. An additional interactive GUI is bundled for ad-hoc testing, allowing users to drag-and-drop a laboratory file and obtain an interpreted output table for immediate review. Because breakpoint guidelines evolve annually, the development team refreshes the embedded resource tables on a rolling basis, ensuring that downstream analyses remain aligned with the most recent CLSI and EUCAST documents. The software is available for free on get.nero.com, with downloads provided via trusted Windows package sources (e.g. winget), always delivering the latest version, and supporting batch installation of multiple applications.
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